| Evaluation |  | Development |  | Piloting / trial production |
| Evaluation of enquiry | | Implementation of technical package | | Scale-up to production volumes |
| Secrecy agreement | | Process development / optimisation / scale-up | | Process & analytical validation |
| Feasibility study | | Risk & safety assessment | | EU notification |
| Raw material availability | | Definition of specification | | Filing of DMF |
| Price indication | | Representative sample / trial quantity | | Commercial production |
| | | | | Continuous process improvement |